Constant-potential environment for activating and synchronizing cardiomyocyte colonies with on-chip ion-depleting perm-selective membranes-Reference-Cited by-同舟云学术

Constant-potential environment for activating and synchronizing cardiomyocyte colonies with on-chip ion-depleting perm-selective membranes

Published:2020 Issue:22 Volume:20 Page:4273-4284
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Yadav Vivek¹²³⁴⁵,Chong Nicholas⁶²³⁴,Ellis Bradley⁶²³⁴,Ren Xiang⁶²³⁴^ORCID,Senapati Satyajyoti¹²³⁴⁵^ORCID,Chang Hsueh-Chia¹²³⁴⁵^ORCID,Zorlutuna Pinar¹²³⁴⁶^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering

2. University of Notre Dame

3. Notre Dame

4. USA

5. Center for Microfluidics and Medical Diagnostics

6. Department of Aerospace and Mechanical Engineering

Abstract

An ion depleted zone was used to impose a high and uniform constant extracellular potential over an entire ∼1000 cell rat cardiomyocyte (rCM) colony on-a-chip, extending single-cell voltage-clamp ion channel studies to an entire normalized colony.

Funder

Semiconductor Research Corporation

Division of Electrical, Communications and Cyber Systems

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/D0LC00809E

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1. Electric Phenomenon: A Disregarded Tool in Tissue Engineering and Regenerative Medicine

2. A current affair: electrotherapy in wound healing