Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations-Reference-Cited by-同舟云学术

Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations

Published:2016 Issue:8 Volume:12 Page:2541-2551
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Tseng Tien-Sheng¹²³⁴⁵,Chuang Show-Mei⁵⁶⁷⁴,Hsiao Nai-Wan⁸⁹¹⁰⁴,Chen Yi-Wen¹¹⁴,Lee Yu-Ching¹²¹³³⁴¹⁴,Lin Chi-Chen⁵⁶⁷⁴,Huang Cheng¹²³⁴,Tsai Keng-Chang¹²³⁴¹⁴

Affiliation:

1. National Research Institute of Chinese Medicine

2. Ministry of Health and Welfare

3. Taipei

4. Taiwan

5. Institute of Biomedical Sciences

6. National Chung Hsing University

7. Taichung

8. Institute of Biotechnology

9. National Changhua University of Education

10. Changhua

11. Cold Spring Biotech Corp.

12. The Center of Translational Medicine

13. Taipei Medical University

14. The Ph.D. Program for Medical Biotechnology

Abstract

Cyclooxygenase (COX; EC: 1.14.99.1), the key enzyme in prostaglandin production in the human body, is a major pharmacological target for developing anti-inflammatory agents.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MB/C6MB00229C

Reference73 articles.

1. Differential Regulation of Cyclooxygenases 1 and 2 by Interleukin-1β, Tumor Necrosis Factor-α, and Transforming Growth Factor-β1 in Human Lung Fibroblasts

2. Cyclooxygenase-2: A Therapeutic Target

3. Cyclooxygenase-2: a potential target in breast cancer

4. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.

5. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues

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