Tuning optimum transfection of gemini surfactant–phospholipid–DNA nanoparticles by validated theoretical modeling-Reference-Cited by-同舟云学术

Tuning optimum transfection of gemini surfactant–phospholipid–DNA nanoparticles by validated theoretical modeling

Published:2019 Issue:3 Volume:11 Page:1037-1046
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Taheri-Araghi Sattar¹²³⁴⁵^ORCID,Chen Ding-Wen¹²³⁴^ORCID,Kohandel Mohammad⁶²⁷⁴⁸,Sivaloganathan Sivabal⁶²⁷⁴⁸,Foldvari Marianna¹²³⁴^ORCID

Affiliation:

1. School of Pharmacy

2. University of Waterloo

3. Kitchener

4. Canada

5. Department of Physics and Astronomy

6. Department of Applied Mathematics

7. Waterloo

8. Centre for Mathematical Medicine

Abstract

Coarse-grained mathematical modeling using the polymorphic structural features of gemini nanoparticles assists designing non-viral gene delivery systems with high transfection efficiency for applications in non-invasive gene therapy.

Funder

Canadian Institutes of Health Research

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Ontario Research Foundation

Canada Research Chairs

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/NR/C8NR06442C

Reference39 articles.

1. Non-viral gene therapy: Gains and challenges of non-invasive administration methods

2. Non-Viral Nucleic Acid Delivery: Key Challenges and Future Directions

3. Advancing nonviral gene delivery: lipid- and surfactant-based nanoparticle design strategies

4. Cationic Liposome–Nucleic Acid Complexes for Gene Delivery and Silencing: Pathways and Mechanisms for Plasmid DNA and siRNA

5. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA

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