Cocoa flavanol consumption improves lower extremity endothelial function in healthy individuals and people with type 2 diabetes

Author:

Bapir Mariam1,Untracht Gavrielle R.23ORCID,Cooke Debbie4,McVey John H.5ORCID,Skene Simon S.1ORCID,Campagnolo Paola5ORCID,Whyte Martin B.1ORCID,Dikaios Nikolaos6,Rodriguez-Mateos Ana7ORCID,Sampson David D.3ORCID,Sampson Danuta M.189ORCID,Heiss Christian110ORCID

Affiliation:

1. Department of Clinical and Experimental Medicine, School of Bioscience & Medicine, University of Surrey, Guildford, United Kingdom

2. Optical+Biomedical Engineering Laboratory, School of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth, Australia

3. Surrey Biophotonics, Advanced Technology Institute, School of Physics and School of Biosciences and Medicine, University of Surrey, Guildford, United Kingdom

4. School of Health Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, United Kingdom

5. Department of Biochemical Sciences, School of Bioscience & Medicine, University of Surrey, Guildford, United Kingdom

6. Mathematics Research Center, Academy of Athens, Athens, Greece

7. Department of Nutritional Sciences, School of Life Course and Population Sciences, Faculty of Life Science and Medicine, King's College London, London, United Kingdom

8. Surrey Biophotonics, Centre for Vision, Speech and Signal Processing and School of Biosciences and Medicine, The University of Surrey, Guildford, United Kingdom

9. University College London, Institute of Ophthalmology, London, United Kingdom

10. Surrey and Sussex NHS Healthcare Trust, Redhill, United Kingdom

Abstract

T2DM individuals exhibit macro- and microvascular dysfunction that is pronounced in the legs. Cocoa acutely increases endothelial function of the brachial and the femoral arteries and dilation of microvasculature in the feet of T2DM and healthy individuals.

Funder

Economic and Social Research Council

University of Surrey

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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