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Modulating the permeability of ferritin channels

Published:2016 Issue:25 Volume:6 Page:21219-21227
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bernacchioni C.¹²³⁴⁵,Ghini V.¹²³⁴⁵,Theil E. C.⁶⁷⁸⁹¹⁰,Turano P.¹²³⁴⁵

Affiliation:

1. CERM

2. University of Florence

3. 50019 Sesto Fiorentino

4. Italy

5. Department of Chemistry

6. Children's Hospital Oakland Research Institute

7. Oakland

8. USA

9. Department of Molecular and Structural Biochemistry

10. North Carolina State University

Abstract

Electric field gradients across the C3 and C4 ferritin channels controls the directional Fe²⁺fluxes towards the catalytic ferroxidase center.

Funder

Ente Cassa di Risparmio di Firenze

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA25056K

Reference41 articles.

1. Re-engineering protein interfaces yields copper-inducible ferritin cage assembly

2. Ferritins for chemistry and for life

3. X-ray structures of ferritins and related proteins

4. Solution and Solid State NMR Approaches To Draw Iron Pathways in the Ferritin Nanocage

5. Loop Electrostatics Modulates the Intersubunit Interactions in Ferritin

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