A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex-Reference-Cited by-同舟云学术

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex

Published:2014 Issue:8 Volume:6 Page:1491-1501
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Novohradsky Vojtech¹²³⁴⁵,Zerzankova Lenka¹²³,Stepankova Jana¹²³,Kisova Anna¹²³,Kostrhunova Hana¹²³,Liu Zhe⁶⁷⁸,Sadler Peter J.⁶⁷⁸,Kasparkova Jana⁴⁵⁹¹⁰,Brabec Viktor¹²³

Affiliation:

1. Institute of Biophysics

2. Academy of Sciences of the Czech Republic

3. CZ-61265 Brno, Czech Republic

4. Department of Biophysics

5. Faculty of Science

6. Department of Chemistry

7. University of Warwick

8. Coventry CV4 7AL, UK

9. Palacky University

10. CZ-77146 Olomouc, Czech Republic

Abstract

An iridium(iii) complex [(η⁵-C₅Me₄C₆H₄C₆H₅)Ir(phen)Cl]PF₆(phen = phenanthroline) exhibits dual effects in killing cancer cells causing nuclear DNA damage and mitochondrial dysfunction simultaneously.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MT/C4MT00112E

Reference34 articles.

1. New trends for metal complexes with anticancer activity

2. Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting

3. Organometallic Anticancer Compounds

4. Exploration of the medical periodic table: towards new targets

5. Organometallic Iridium(III) Cyclopentadienyl Anticancer Complexes Containing C,N-Chelating Ligands

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