Chemo-enzymatic synthesis of (E)-2,3-diaryl-5-styryl-trans-2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90)-Reference-Cited by-同舟云学术

Chemo-enzymatic synthesis of (E)-2,3-diaryl-5-styryl-trans-2,3-dihydrobenzofuran-based scaffolds and their in vitro and in silico evaluation as a novel sub-family of potential allosteric modulators of the 90 kDa heat shock protein (Hsp90)

Published:2018 Issue:20 Volume:16 Page:3741-3753
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bassanini Ivan¹²³⁴⁵,D'Annessa Ilda¹²³⁴,Costa Massimo¹²³⁴,Monti Daniela¹²³⁴^ORCID,Colombo Giorgio¹²³⁴⁶^ORCID,Riva Sergio¹²³⁴^ORCID

Affiliation:

1. Istituto di Chimica del Riconoscimento Molecolare

2. CNR

3. Milano

4. Italy

5. Università degli Studi di Milano

6. Università degli Studi di Pavia

Abstract

Efficient chemo-enzymatic synthesis of dihydrobenzofurans and evaluation of their activities towards the protein Hsp90.

Funder

Associazione Italiana per la Ricerca sul Cancro

Fondazione Cariplo

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00644J

Reference58 articles.

1. S. E. Jackson , in Molecular Chaperones , Springer , Berlin, Heidelberg , 2012 , vol. 328 , pp. 155–240

2. HSP90 at the hub of protein homeostasis: emerging mechanistic insights

3. Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation

4. Heat shock protein 90 in neurodegenerative diseases

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