Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction-Reference-Cited by-同舟云学术

Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction

Published:2017 Issue:27 Volume:15 Page:5820-5823
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Cong-Xiang¹²³⁴⁵,Liu Rui-Juan¹²³⁴⁵,Yin Kun¹²³⁴⁵,Wen Li-Rong¹²³⁴⁵^ORCID,Li Ming¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory Base of Eco-Chemical Engineering

2. College of Chemistry and Molecular Engineering

3. Qingdao University of Science and Technology

4. Qingdao 266042

5. P. R. China

Abstract

A DABCO-promoted three-component reaction of β-ketothioamides, arylglyoxals and 2-cyanoacetate to construct disulfides tethered pyrroles has been developed.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00655A

Reference64 articles.

1. Metal-free cross-coupling reaction of aldehydes with disulfides by using DTBP as an oxidant under solvent-free conditions

2. Syntheses of Sulfides and Selenides through Direct Oxidative Functionalization of C(sp3)–H Bond

3. PdCl2-Promoted Electrophilic Annulation of 2-Alkynylphenol Derivatives with Disulfides or Diselenides in the Presence of Iodine

4. Synthesis and in vitro antiproliferative evaluation of novel nonsymmetrical disulfides bearing 1,3,4-oxadiazole moiety

5. Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities

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