Derivatisation of buforin IIb, a cationic henicosapeptide, to afford its complexation to platinum(ii) resulting in a novel platinum(ii)–buforin IIb conjugate with anti-cancer activity-Reference-Cited by-同舟云学术

Derivatisation of buforin IIb, a cationic henicosapeptide, to afford its complexation to platinum(ii) resulting in a novel platinum(ii)–buforin IIb conjugate with anti-cancer activity

Published:2016 Issue:33 Volume:45 Page:13038-13041
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Parker J. P.¹²³⁴⁵,Devocelle M.¹²³⁴⁵,Morgan M. P.⁶³⁴⁵,Marmion C. J.¹²³⁴⁵

Affiliation:

1. Centre for Synthesis and Chemical Biology

2. Department of Pharmaceutical & Medicinal Chemistry

3. Royal College of Surgeons in Ireland

4. Dublin 2

5. Ireland

6. Molecular & Cellular Therapeutics

Abstract

Herein we report the synthesis and anti-cancer activity of buforin IIb, its novel malonate derivative malBuf and its Pt(ii) complex cis-[Pt(NH₃)₂(malBuf_–2H)].

Funder

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT01510G

Reference14 articles.

1. The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

2. The First Solid-Phase Synthesis of a Peptide-Tethered Platinum(II) Complex

3. Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

4. Solid-phase synthesis and DNA binding studies of dichloroplatinum(ii) conjugates of dicarba analogues of octreotide as new anticancer drugs

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