Isatin-based benzyloxybenzene derivatives as monoamine oxidase inhibitors with neuroprotective effect targeting neurogenerative disease treatment

Author:

Benny Feba1,Oh Jong Min2,Kumar Sunil1,Abdelgawad Mohamed A.3,Ghoneim Mohammed M.4,Abdel-Bakky Mohamed Sadek5,Kukerti Neelima6,Jose Jobin7ORCID,Kim Hoon2ORCID,Mathew Bijo1ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India

2. Department of Pharmacy, Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea

3. Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia

4. Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia

5. Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 51452, Saudi Arabia

6. School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand 248002, India

7. Department of Pharmaceutics, NGSM Institute of Pharmaceutical Science, NITTE University, Mangalore, Karnataka 575018, India

Abstract

Eighteen isatin-based benzyloxybenzaldehyde derivatives from three subseries, ISB, ISFB, and ISBB, were synthesized and their ability to inhibit monoamine oxidase (MAO) was evaluated.

Funder

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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