Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two trans coordination sites-Reference-Cited by-同舟云学术

Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two trans coordination sites

Published:2016 Issue:8 Volume:7 Page:4922-4929
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

van Rixel V. H. S.¹²³⁴,Siewert B.¹²³⁴,Hopkins S. L.¹²³⁴,Askes S. H. C.¹²³⁴,Busemann A.¹²³⁴,Siegler M. A.⁵⁶⁷⁸,Bonnet Sylvestre¹²³⁴^ORCID

Affiliation:

1. Leiden Institute of Chemistry

2. Universiteit Leiden

3. Leiden

4. Netherlands

5. Small Molecule X-ray Crystallography Facility

6. Johns Hopkins University

7. Baltimore

8. USA

Abstract

In this work, two new photopharmacological ruthenium prodrugs are described that can be activated by green light. Cell death occurs via apoptosis; it is not a consequence of singlet oxygen generation, but of light-induced photosubstitution reactions.

Funder

European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00167J

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