Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models-Reference-Cited by-同舟云学术

Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

Published:2022 Issue:24 Volume:10 Page:7133-7148
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Caracena Thomas¹,Blomberg Rachel¹,Hewawasam Rukshika S.¹,Fry Zoe E.¹,Riches David W. H.²³⁴⁵,Magin Chelsea M.¹³⁶^ORCID

Affiliation:

1. Department of Bioengineering, University of Colorado, Denver | Anschutz Medical Campus, USA

2. Program in Cell Biology, Department of Pediatrics, National Jewish Health, USA

3. Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus, USA

4. Department of Research, Veterans Affairs Eastern Colorado Health Care System, USA

5. Department of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, USA

6. Department of Pediatrics, University of Colorado, Anschutz Medical Campus, USA

Abstract

Increased microenvironmental stiffness and alveolar epithelial cells were both required to drive fibroblast activation in biomaterial-based 3D models of pulmonary fibrosis.

Funder

American Thoracic Society

National Heart, Lung, and Blood Institute

Division of Materials Research

National Cancer Institute

U.S. Department of Defense

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00827K

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