Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis-Reference-Cited by-同舟云学术

Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis

Published:2015 Issue:41 Volume:5 Page:32497-32504
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Solum Eirik Johansson¹²³⁴⁵,Cheng Jing-Jy⁶⁷⁸⁹¹⁰,Sylte Ingebrigt¹¹¹²¹³¹⁴⁵,Vik Anders¹²³⁴⁵,Hansen Trond Vidar¹²³⁴⁵

Affiliation:

1. Department of Pharmaceutical Chemistry

2. School of Pharmacy

3. University of Oslo

4. N-0316 Oslo

5. Norway

6. National Research Institute of Chinese Medicine

7. Taipei

8. Taiwan

9. Institute of Biophotonics

10. National Yang-Ming University

11. Department of Medical Biology

12. Faculty of Health Sciences

13. UiT – The Arctic University of Norway

14. 9037 Tromsø

Abstract

Structural-activity studies on the steroid 2-methoxyestradiol revealed a new analog that exhibited potent inhibition of angiogenesis and cytotoxic effects.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA03570H

Reference31 articles.

1. Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells

2. Therapeutic Promises of 2-Methoxyestradiol and Its Drug Disposition Challenges

3. The cytotoxic effects of estradiol-17β, catecholestradiols and methoxyestradiols on dividing MCF-7 and Hela cells

4. 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

5. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

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