Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants-Reference-Cited by-同舟云学术

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

Published:2017 Issue:6 Volume:8 Page:4352-4362
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Meisl Georg¹²³⁴^ORCID,Yang Xiaoting⁵⁶⁷⁸^ORCID,Dobson Christopher M.¹²³⁴,Linse Sara⁵⁶⁷⁸^ORCID,Knowles Tuomas P. J.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. University of Cambridge

3. Cambridge CB2 1EW

4. UK

5. Chemistry Department and Molecular Protein Science

6. Lund University

7. SE221 00 Lund

8. Sweden

Abstract

The aggregation of Aβ42, linked to Alzheimer's disease, can be altered significantly by variations of the ionic strength of the solution, providing a means to relate the differences in aggregation mechanism of other Ab variants to changes in electrostatic interactions.

Funder

Frances and Augustus Newman Foundation

European Research Council

Biotechnology and Biological Sciences Research Council

Swedish Research Council

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC00215G