A pH responsive complexation-based drug delivery system for oxaliplatin-Reference-Cited by-同舟云学术

A pH responsive complexation-based drug delivery system for oxaliplatin

Published:2017 Issue:6 Volume:8 Page:4458-4464
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Li Bin¹²³⁴⁵,Meng Zhao⁶⁷⁸⁵,Li Qianqian¹²³⁴⁵,Huang Xiayang¹²³⁴⁵,Kang Ziyao⁶⁷⁸⁵,Dong Huajin⁶⁷⁸⁵,Chen Junyi¹²³⁴⁵,Sun Ji¹²³⁴⁵,Dong Yansheng⁶⁷⁸⁵,Li Jian¹²³⁴⁵,Jia Xueshun¹²³⁴⁵,Sessler Jonathan L.¹²³⁴⁵^ORCID,Meng Qingbin⁶⁷⁸⁵,Li Chunju¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Center for Supramolecular Chemistry and Catalysis

3. Shanghai University

4. Shanghai 200444

5. P. R. China

6. State Key Laboratory of Toxicology and Medical Countermeasures

7. Beijing Institute of Pharmacology and Toxicology

8. Beijing 100850

Abstract

A responsive drug delivery system (DDS) for oxaliplatin (OX) has been designed with a view to overcoming several common drawbacks associated with this widely used anticancer agent, including fast degradation/deactivation in the blood stream, lack of tumor selectivity, and low bioavailability.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC01438D

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