Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961

Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966

Published:2019 Issue:3 Volume:10 Page:943-945
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hoffmann Reinhard W.¹²³^ORCID,Schmalz Hans-Günther⁴⁵⁶³^ORCID,Koert Ulrich¹²³^ORCID,Pierens Gregory K.⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Fachbereich Chemie der Philipps Universität Marburg

2. D-35032 Marburg

3. Germany

4. Department of Chemistry

5. University of Cologne

6. D-50939 Koeln

7. The Centre for Advanced Imaging

8. The University of Queensland

9. St. Lucia

10. Australia

Abstract

We note that some features of the NMR spectra deposited for the purported isomeric metacolchicines are not compatible with the assignment of those isomers as being atrop-diastereomers.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC90247J

Reference7 articles.

1. Metacolchicine, a New Colchicinoid from Sandersonia aurantiaca

2. Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids

3. Isolation of atropisomers in both the isocolchicide and colchicide series of alkaloids and determination of their chiroptical properties

4. Stereochemical variations on the colchicine motif. Peracid oxidation of thiocolchicone. Synthesis, conformation and inhibition of microtubule assembly

5. Conformational isomerism and its relation to the mutarotation of isocolchicine

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