Direct synthesis of annulated indoles through palladium-catalyzed double alkylations

Author:

Gao Yadong12345,Li Jianhua1234,Bai Songlin564,Tu Daoquan1234,Yang Chao12345ORCID,Ye Zhiwen1234,Hu Bingcheng1234,Qi Xiangbing56478,Jiang Chao1234ORCID

Affiliation:

1. School of Chemical Engineering

2. Nanjing University of Science and Technology

3. Nanjing 210094

4. P. R. China

5. National Institute of Biological Sciences

6. Beijing 102206

7. Tsinghua Institute of Multidisciplinary Biomedical Research

8. Tsinghua University

Abstract

A facile, one-step synthesis of annulated indoles from (N–H) indoles and dibromoalkanes was developed through a palladium-catalyzed double alkylation process.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

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