A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters

Author:

Dong Lei12,Zhang Min-Yu1,Han Hai-Hao1,Zang Yi3,Chen Guo-Rong1,Li Jia3,He Xiao-Peng1,Vidal Sébastien24ORCID

Affiliation:

1. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China

2. Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Laboratoire de Chimie Organique 2-Glycochimie, UMR 5246, CNRS, Université Claude Bernard Lyon 1, Université de Lyon, 1 Rue Victor Grignard, F-69622 Villeurbanne, France

3. National Centre for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai 201203, P. R. China

4. Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France

Abstract

We report a general strategy for the fluorogenic sensing of glycosidases in cells based on aggregation-induced emission of glycoclusters.

Funder

China Scholarship Council

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Université Claude Bernard Lyon 1

Fundamental Research Funds for the Central Universities

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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