I2-Mediated 2H-indazole synthesis via halogen-bond-assisted benzyl C–H functionalization
Author:
Affiliation:
1. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education)
2. Department of Chemistry
3. Tsinghua University
4. Beijing 100084
5. China
6. Center of Basic Molecular Science (CBMS)
Abstract
I2-Mediated benzyl C–H functionalization has been developed for the synthesis of 2H-indazoles. Experiments and DFT calculation reveal halogen bond assistance and synergistic H-abstraction in this reaction.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01827K
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