Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation-Reference-Cited by-同舟云学术

Synthesis of chiral seven-membered β-substituted lactams via Rh-catalyzed asymmetric hydrogenation

Published:2018 Issue:45 Volume:16 Page:8819-8823
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Huang Yi¹²³⁴⁵,Li Pan¹²³⁴⁵,Dong Xiu-Qin¹²³⁴⁵^ORCID,Zhang Xumu¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Biomedical Polymers

2. Engineering Research Centre of Organosilicon Compounds & Materials

3. Ministry of Education

4. College of Chemistry and Molecular Sciences

5. Wuhan University

Abstract

Various chiral seven-membered β-substituted lactams were successfully prepared through Rh/bisphosphine-thiourea ligand (ZhaoPhos)-catalyzed asymmetric hydrogenation with up to >99% conversion, 99% yield, and >99% ee.

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02231C

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