Drug delivery, biodistribution and anti-EGFR activity: theragnostic nanoparticles for simultaneous in vivo delivery of tyrosine kinase inhibitors and kinase activity biosensors

Author:

Bofinger Robin1,Weitsman Gregory2ORCID,Evans Rachel23ORCID,Glaser Matthias14,Sander Kerstin14ORCID,Allan Helen1ORCID,Hochhauser Daniel3,Kalber Tammy L.5ORCID,Årstad Erik14,Hailes Helen C.1ORCID,Ng Tony23ORCID,Tabor Alethea B.1ORCID

Affiliation:

1. Department of Chemistry, University College London, 20, Gordon Street, London WC1H 0AJ, UK

2. School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 1UL, UK

3. UCL Cancer Institute, Paul O'Gorman Building, University College London, London WC1E 6DD, UK

4. Centre for Radiopharmaceutical Chemistry, Kathleen Lonsdale Building, 5 Gower Place, London WC1E 6BS, UK

5. Centre for Advanced Biomedical Imaging, Paul O'Gorman Building, University College London, London WC1E 6DD, UK

Abstract

We report the development of targeted theragnostic lipid/peptide/DNA lipopolyplexes for delivery of both a tyrosine kinase inhibitor, and plasmid DNA coding for a biosensor. These are used to quantify EGFR inhibition in cancer cell lines in vivo.

Funder

Medical Research Council

Cancer Research UK

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3