The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity
Author:
Affiliation:
1. Medicinal Chemistry
2. Monash Institute of Pharmaceutical Sciences
3. Monash University
4. Parkville 3052
5. Australia
6. Drug Delivery
7. Disposition and Dynamics
Abstract
The synthesis and NMR structure of a polypeptin, a depsipeptide that shows anti-bacterial activity against drug resistant bacteria has been achieved.
Funder
National Health and Medical Research Council
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01493G
Reference22 articles.
1. New antibiotics for bad bugs: where are we?
2. Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates
3. Antibiotics in the clinical pipeline in 2013
4. Circulin, an Antibiotic from a Member of the Bacillus circulans Group
5. The structure of permetin A, a new polypeptin type antibiotic produced by Bacillus circulans.
Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Effects of polypeptidin feeding on growth and intestinal flora of Apostichopus japonicus;Aquaculture Reports;2024-10
2. Structure–Activity Relationship Study of Antimicrobial Peptide PE2 Delivered Novel Linear Derivatives with Potential of Eradicating Biofilms and Low Incidence of Drug Resistance;Journal of Medicinal Chemistry;2023-06-27
3. Genetics and Biochemistry of Sporulation in Endospore-Forming Bacteria (Bacillus): A Prime Example of Developmental Biology;Developmental Biology in Prokaryotes and Lower Eukaryotes;2021
4. Structure and antifungal activity of pelgipeptins from Paenibacillus elgii against phytopathogenic fungi;Pesticide Biochemistry and Physiology;2020-02
5. Engineered biosynthesis of cyclic lipopeptide locillomycins in surrogate host Bacillus velezensis FZB42 and derivative strains enhance antibacterial activity;Applied Microbiology and Biotechnology;2019-04-15
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3