A nanotherapeutic approach to selectively eliminate metastatic breast cancer cells by targeting cell surface GRP78

Author:

Shin Jaeho1,Kim Baksun1,Lager Tyson W.2,Mejia Franklin1,Guldner Ian3,Conner Clay2,Zhang Siyuan4,Panopoulos Athanasia D.5267ORCID,Bilgicer Basar158ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 465567, USA

2. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA

3. Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA

4. Department of Pathology, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA

5. Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN 46556, USA

6. Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA

7. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA

8. Berthiaume Institute for Precision Health, University of Notre Dame, Notre Dame, IN 46556, USA

Abstract

Cell surface GRP78 (sGRP78) targeting nanoparticles were engineered to achieve maximum targeting efficiency while preserving selectivity. Optimized drug-loaded nanoparticles demonstrated significant inhibition of seeded breast cancer cells in vivo.

Funder

American Cancer Society

Walther Cancer Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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