Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe])-Reference-Cited by-同舟云学术

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe])

Published:2018 Issue:35 Volume:16 Page:6531-6536
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Horie Naohiro¹²³⁴,Kumagai Shinji⁵⁶⁷⁴^ORCID,Kotobuki Yutaro¹²³⁴,Yamaguchi Takao¹²³⁴^ORCID,Obika Satoshi¹²³⁴⁸^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Osaka University

3. Osaka 565-0871

4. Japan

5. Soyaku. Innovative Research Division

6. Mitsubishi Tanabe Pharma Corporation

7. Yokohama 227-0033

8. National Institutes of Biomedical Innovation

Abstract

The GuNA[NMe]-modified oligonucleotides exhibited excellent duplex-forming ability towards the complementary single-stranded DNA and RNA, and showed robust enzymatic stability.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01307A

Reference31 articles.

1. Making sense of antisense oligonucleotides: A narrative review

2. Advances in the delivery of RNA therapeutics: from concept to clinical reality

3. Antisense oligonucleotides: modifications and clinical trials

4. Antisense drug discovery and development

5. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

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