Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1-Reference-Cited by-同舟云学术

Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1

Published:2017 Issue:26 Volume:53 Page:3673-3676
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Li Ao¹²³⁴,Yadav Rahul⁵⁶⁷⁴,White Jessica K.⁸⁹¹⁰⁴^ORCID,Herroon Mackenzie K.¹¹¹²²³⁴,Callahan Brian P.¹¹³¹⁴⁴,Podgorski Izabela¹¹¹²²³⁴,Turro Claudia⁸⁹¹⁰⁴,Scott Emily E.⁵⁶⁷⁴,Kodanko Jeremy J.¹²³⁴¹⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Wayne State University

3. Detroit

4. USA

5. Department of Medicinal Chemistry

6. University of Michigan

7. Ann Arbor

8. Department of Chemistry and Biochemistry

9. The Ohio State University

10. Columbus

11. Department of Pharmacology

12. School of Medicine

13. Binghamton University

14. Binghamton

15. Barbara Ann Karmanos Cancer Institute

Abstract

Visible light triggers release of the prostate cancer drug abiraterone in cancer cells and achieves photoactivated cytochrome P450 binding.

Funder

National Science Foundation

National Institute of General Medical Sciences

National Institute of Biomedical Imaging and Bioengineering

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C7CC01459G

Reference38 articles.

1. The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

2. Mammalian cytochromes P450—Importance of tissue specificity

3. Insect P450 inhibitors and insecticides: challenges and opportunities

4. Cytochromes P450 and metabolism of xenobiotics

5. Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy

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