Inspired by lubricin: a tailored cartilage-armor with durable lubricity and autophagy-activated antioxidation for targeted therapy of osteoarthritis-Reference-Cited by-同舟云学术

Inspired by lubricin: a tailored cartilage-armor with durable lubricity and autophagy-activated antioxidation for targeted therapy of osteoarthritis

Published:2024 Issue: Volume: Page:
ISSN:2051-6347
Container-title:Materials Horizons
language:en
Short-container-title:Mater. Horiz.

Author:

Yu Peng¹^ORCID,Peng Xu²,Sun Hui¹,Xin Qiangwei¹,Kang Han³,Wang Peng¹,Zhao Yao¹,Xu Xinyuan¹,Zhou Guangwu⁴,Xie Jing¹^ORCID,Li Jianshu¹⁵^ORCID

Affiliation:

1. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Med-X Center for Materials, Sichuan University, Chengdu 610065, P. R. China

2. Experimental and Research Animal Institute, Sichuan University, Chengdu 610207, P. R. China

3. Life Science Core Facilities, College of Life Sciences, Sichuan University, Chengdu 610065, P. R. China

4. School of Aeronautics and Astronautics, Sichuan University, Chengdu 610207, P. R. China

5. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P. R. China

Abstract

By mimicking natural lubricin, a tailored polyzwitterionic armor, which exhibited cartilage targeting, anti-degradation and anti-oxidation and chondrogenesis properties, was designed for drug-free osteoarthritis therapy.

Funder

National Natural Science Foundation of China

State Key Laboratory of Polymer Materials Engineering

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MH/D4MH00812J

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