Design and synthesis of a bivalent probe targeting the putative mu opioid receptor and chemokine receptor CXCR4 heterodimer-Reference-Cited by-同舟云学术

Design and synthesis of a bivalent probe targeting the putative mu opioid receptor and chemokine receptor CXCR4 heterodimer

Published:2020 Issue:1 Volume:11 Page:125-131
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Reinecke Bethany A.¹²³⁴,Kang Guifeng¹²³⁴,Zheng Yi¹²³⁴,Obeng Samuel¹²³⁴,Zhang Huijun⁵⁶⁷⁸⁹,Selley Dana E.¹⁰²⁴,An Jing⁵⁶⁷⁸⁹,Zhang Yan¹²³⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. Virginia Commonwealth University

3. Richmond

4. USA

5. Department of Medicine

6. Division of Infectious Diseases

7. School of Medicine

8. University of California San Diego

9. La Jolla

10. Department of Pharmacology and Toxicology

Abstract

The first bivalent ligand targeting the putative heterodimer of the mu opioid receptor and the chemokine receptor CXCR4.

Funder

National Institute on Drug Abuse

National Institute of Mental Health

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00433E

Reference63 articles.

1. Opioids and Viral Infections: A Double-Edged Sword

2. Opioids and HIV/HCV Infection

3. P. V. B. Reddy , S.Pilakka-Kanthikeel , S. K.Saxena , Z.Saiyed and M. P. N.Nair , Interactive Effects of Morphine on HIV Infection , https://www.hindawi.com/journals/art/2012/953678/, (accessed October 30, 2017 )

4. Cannabinoids and morphine differentially affect HIV-1 expression in CD4+ lymphocyte and microglial cell cultures

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Study of G protein-coupled receptors dimerization: From bivalent ligands to drug-like small molecules;Bioorganic Chemistry;2023-11

2. Novel bivalent ligands carrying potential antinociceptive effects by targeting putative mu opioid receptor and chemokine receptor CXCR4 heterodimers;Bioorganic Chemistry;2022-03

3. Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity;Journal of Medicinal Chemistry;2021-05-24

4. Design of bivalent ligands targeting putative GPCR dimers;Drug Discovery Today;2021-01

5. Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry;ACS Medicinal Chemistry Letters;2020-09-13