A bottom-up approach to the ion recognition mechanism of K<sup>+</sup> channels from laser spectroscopy of hydrated partial peptide–alkali metal ion complexes-Reference-Cited by-同舟云学术

A bottom-up approach to the ion recognition mechanism of K⁺ channels from laser spectroscopy of hydrated partial peptide–alkali metal ion complexes

Published:2022 Issue:35 Volume:24 Page:20803-20812
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Suzuki Yukina¹²,Hirata Keisuke¹³⁴,Lisy James M.⁴⁵^ORCID,Ishiuchi Shun-ichi¹³⁴^ORCID,Fujii Masaaki¹²⁴^ORCID

Affiliation:

1. Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, 226-8503, Japan

2. School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa, 226-8503, Japan

3. Department of Chemistry, School of Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan

4. Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovation Research, Tokyo Institute of Technology, 4259, Nagatsuta-cho, Midori-ku, Yokohama, 226-8503, Japan

5. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

Abstract

Hydration impacts alkali metal ion–peptide conformations for the largest and smallest ions, but has only a small effect on K+, the most permeable ion in K+ channels.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP01667B

Reference45 articles.

1. Potassium channels

2. A Mechanism for Ion Selectivity in Potassium Channels: Computational Studies of Cation-π Interactions

3. Mutations in the K+ channel signature sequence

4. Conduction and selectivity in potassium channels

5. The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity

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