Bioinspired photo-crosslinkable self-assembling peptides with pH-switchable “on–off” luminescence

Author:

Pugliese Raffaele12,Montuori Monica3,Gelain Fabrizio14ORCID

Affiliation:

1. Tissue Engineering Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapies-ISBReMIT, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, FG, Italy

2. NeMO Lab, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy

3. Biotechnology and Biosciences Department, University of Milano-Bicocca, 20162 Milan, Italy

4. Center for Nanomedicine and Tissue Engineering (CNTE), ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy

Abstract

Drawing inspiration from the biological functions of tyrosine, we present a photo-cross-linking approach based on the ruthenium-complex-catalyzed conversion of tyrosine to dityrosine upon light irradiation of a tyrosine-containing self-assembling peptide.

Funder

Ministero della Salute

Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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