Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones-Reference-Cited by-同舟云学术

Efficient construction of bioactive trans-5A5B6C spirolactones via bicyclo[4.3.0] α-hydroxy ketones

Published:2018 Issue:7 Volume:16 Page:1163-1166
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhu Y. J.¹²³⁴⁵^ORCID,Huo J. Q.⁶⁷⁸⁵,Fan Z. J.¹²³⁴⁵,Wu Q. F.¹²³⁴⁵,Li X.¹²³⁴⁵,Zhou S.¹²³⁴⁵,Xiong L. X.¹²³⁴⁵,Kalinina T.⁹¹⁰¹¹,Glukhareva T.⁹¹⁰¹¹

Affiliation:

1. State Key Laboratory of Elemento-Organic Chemistry

2. College of Chemistry

3. Nankai University

4. Tianjin 300071

5. P. R. China

6. College of Plant Protection

7. Agricultural University of Hebei

8. Baoding 071001

9. The Ural Federal University Named after the First President of Russia B. N. Yeltsin

10. Ekaterinburg 620002

11. Russia

Abstract

The intricate 5_A5_B6_C-ring fusion topologies of tricyclic spiranoid β-hydroxybutyrolactones with environmentally benign characteristics and moderate biological activities were synthesized through lactonization of the key intermediate trans-α-hydroxyindenones with malonates by an efficient and convenient short synthetic procedure.

Funder

National Natural Science Foundation of China

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C7OB02701J

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1. A Stereoselective Total Synthesis of (.+-.)-Alliacol A and Congeners of Marasmius Alliaceus

2. A stereoselective total synthesis of alliacane lactones