Lipid–polymer hybrid nanoparticles loaded with <i>N</i>-acetylcysteine for the modulation of neuroinflammatory biomarkers in human iPSC-derived PSEN2 (N141I) astrocytes as a model of Alzheimer's disease-Reference-Cited by-同舟云学术

Lipid–polymer hybrid nanoparticles loaded with N-acetylcysteine for the modulation of neuroinflammatory biomarkers in human iPSC-derived PSEN2 (N141I) astrocytes as a model of Alzheimer's disease

Published:2024 Issue:21 Volume:12 Page:5085-5097
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Vargas-Barona Alondra¹,Bernáldez-Sarabia Johanna¹,Castro-Ceseña Ana B.¹²^ORCID

Affiliation:

1. Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California (CICESE), Carretera Ensenada- Tijuana No. 3918, Zona Playitas, C.P. 22860, Ensenada, Baja California, Mexico

2. CONAHCYT-Departamento de Innovación Biomédica, Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California (CICESE), Carretera Ensenada-Tijuana No. 3918, Zona Playitas, C.P. 22860, Ensenada, Baja California, Mexico

Abstract

Lipid–polymer hybrid nanoparticles loaded with N-acetyl cysteine reduced the expression of the proinflammatory genes IL-1β, APP, and GFAP, and the secretion of IL-6, IL-1β and INF-γ in human iPSC-derived PSEN2 (N141I) astrocytes, as a model of AD.

Funder

Consejo Nacional de Ciencia y Tecnología

Centro de Investigación Científica y de Educación Superior de Ensenada, Baja California

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00521J

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