CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents-Reference-Cited by-同舟云学术

CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents

Published:2023 Issue:19 Volume:13 Page:13169-13176
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Peng Cong-Min¹,Wang Shih-Wei²³⁴^ORCID,Hwang Yi-Lin¹,Sun Wen-Chun²⁵,Chiu Li-Pin⁶⁷,Liu Yi-Ting¹,Lai Yu-Wei⁸⁹,Lee Hsueh-Yun¹¹⁰¹¹^ORCID

Affiliation:

1. School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

2. Institute of Biomedical Sciences, MacKay Medical College, New Taipei City, Taiwan

3. Department of Medicine, MacKay Medical College, New Taipei City, Taiwan

4. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan

5. Division of Colon and Rectal Surgery, Department of Surgery, MacKay Memorial Hospital, Taipei, Taiwan

6. Division of General Surgery, Taipei City Hospital Chushing Branch, Taipei, Taiwan

7. General Education Center, University of Taipei, Taipei, Taiwan

8. Division of Urology, Taipei City Hospital Renai Branch, Taipei, Taiwan

9. Department of Urology, School of Medicine and Shu-Tien Urological Science Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan

10. PhD Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan

11. TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, Taiwan

Abstract

In situ CuI-mediated cyclization helps construct N-aryl-5,6,7-trimethoxybenzimidazoles. Compound 10 displayed potent antiproliferative activity and inhibitory activity of tubulin polymerization.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA01927F

Reference20 articles.

1. Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

2. Microtubules as a target for anticancer drugs

3. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

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5. Medicinal Chemistry of Combretastatin A4: Present and Future Directions

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4. Correction: CuI-mediated synthesis of 1-aryl-5,6,7-trimethoxybenzimidazoles as potent antitubulin agents;RSC Advances;2023