Nitric oxide/paclitaxel micelles enhance anti-liver cancer effects and paclitaxel sensitivity by inducing ferroptosis, endoplasmic reticulum stress and pyroptosis

Author:

Li Huilan1,Deng Xiaoyu2,Zhang Ziwei2,Yang Zunhua2ORCID,Huang Hesong1,Ye Xide2,Zhong Linyun2,Xu Guoliang2,Liu Ronghua2,Fang Yuanying1ORCID

Affiliation:

1. National Engineering Research Center for Manufacturing Technology of TCM Solid Preparation, Jiangxi University of Chinese Medicine, Nanchang 330006, China

2. College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China

Abstract

The paclitaxel-containing micelle bearing NO donor (NO/PTX) exhibited improved anticancer effect in Bel-7402 cells and H22 xenograft mice by the modes of ferroptosis, pyroptosis, ERS and apoptosis-associated networks.

Funder

Jiangxi Provincial Department of Science and Technology

National Natural Science Foundation of China

Education Department of Jiangxi Province

Jiangxi University of Traditional Chinese Medicine

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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