Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation,<i>in silico</i>and preliminary kinetic studies-Reference-Cited by-同舟云学术

Theophylline-based hybrids as acetylcholinesterase inhibitors endowed with anti-inflammatory activity: synthesis, bioevaluation,in silicoand preliminary kinetic studies

Published:2023 Issue:36 Volume:13 Page:25616-25634
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Elgazar Abdullah A.¹^ORCID,El-Domany Ramadan A.²,Eldehna Wagdy M.³^ORCID,Badria Farid A.⁴

Affiliation:

1. Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, P.O. Box 33516, Kafrelsheikh, Egypt

2. Department of Microbiology and Immunology, Faculty of Pharmacy, Kafrelsheikh University, P.O. Box 33516, Kafrelsheikh, Egypt

3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, P.O. Box 33516, Kafrelsheikh, Egypt

4. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

Abstract

In this study, conjugation of theophylline with different compounds of natural origin led to new hybrids with dual activity against cholinergic and inflammatory pathways as potential agents for management of Alzheimer's disease (AD).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA04867E

Reference82 articles.

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