Enantioselective total synthesis of the unnatural enantiomer of quinine-Reference-Cited by-同舟云学术

Enantioselective total synthesis of the unnatural enantiomer of quinine

Published:2019 Issue:41 Volume:10 Page:9433-9437
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Shiomi Shinya¹²³⁴⁵,Misaka Remi¹²³⁴⁵,Kaneko Mayu¹²³⁴⁵,Ishikawa Hayato¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry

2. Graduate School of Science and Technology

3. Kumamoto University

4. Kumamoto 860-8555

5. Japan

Abstract

A practical enantioselective total synthesis of the unnatural (+)-quinine and (−)-9-epi-quinine enantiomers, which are important organocatalysts, is reported.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Uehara Memorial Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC03879E

Reference38 articles.

1. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria

2. Nucleophilic Chiral Amines as Catalysts in Asymmetric Synthesis

3. Asymmetric Organic Catalysis with Modified Cinchona Alkaloids

4. Recent Developments in the Use of Catalytic Asymmetric Ammonium Enolates in Chemical Synthesis

5. Recent Advances in Asymmetric Phase-Transfer Catalysis

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