The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid-Reference-Cited by-同舟云学术

The enhanced antitumor activity of the polymeric conjugate covalently coupled with docetaxel and docosahexaenoic acid

Published:2022 Issue:13 Volume:10 Page:3454-3465
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Dong Peng¹,Liu Jiaojiao¹,Lv Hongshuai¹,Wu Jiaan¹,Zhang Naining¹,Wang Si²,Li Xiaohai²,Hu Jinghua²,Wang Anny²,Li Daisy J.²,Wang Dandan³,Cao Shengnan³,Xie Liangyu³,Shi Yikang¹^ORCID

Affiliation:

1. National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based Medicine, Shandong University, Qingdao 266237, Shandong, China

2. Santolecan Pharmaceuticals LLC, 1261 Islamorada Drive, Jupiter, Florida, 33458, USA

3. Bone Biomechanics Engineering Laboratory of Shandong Province, Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China

Abstract

The polymer dual drug conjugate synthesized by coupling docetaxel (DTX) and docosahexaenoic acid (DHA) with bifunctionalized dextran is selectively accumulated in tumor and nearly eradicates all MCF-7 tumors bearing in nude mice.

Funder

Major Scientific and Technological Innovation Project of Shandong Province

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00337F

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1. Carbohydrate-based amphiphilic nano delivery systems for cancer therapy

2. Advances in Nanocarriers for Effective Delivery of Docetaxel in the Treatment of Lung Cancer: An Overview