Efficient synthesis of 6,6′-diamido-2,2′-dipicolylamine ligands for potential phosphate anion sensing

Author:

Wang Shuai12,Gong Lichong3,El Fakhri Georges1,Wang Junfeng1ORCID

Affiliation:

1. Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, Massachusetts 02114, USA

2. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China

3. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Suite 2301, Charlestown, Massachusetts 02129, USA

Abstract

Through retrosynthetic analysis, functionalized 6,6′-diamido-2,2′-dipicolylamines (DA-DPAs) have been efficiently synthesized, which may accelerate the development of selective probes towards phosphate anions.

Funder

National Institutes of Health

National Institute on Aging

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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