Enhancing the accuracy of mid-infrared spectroscopy-based liver steatosis quantification using digital image analysis as a reference

Author:

Rienda Iván1,Ten-Doménech Isabel2,Moro Erika3,Moreno-Torres Marta345,Pérez-Rojas Judith1,Pareja Eugenia46,Pérez-Rubio Álvaro6,Trullenque Ramón6,Jover Ramiro345,Lendl Bernhard7ORCID,Pérez-Guaita David8ORCID,Kuligowski Julia2,Castell Jose V.345,Quintás Guillermo9ORCID

Affiliation:

1. Pathology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain

2. Neonatal Research Group, Health Research Institute La Fe, Valencia, Spain

3. Departamento de Bioquímica y Biología Molecular, Universidad de Valencia, Valencia, Spain

4. Unit for Experimental Hepatology, Health Research Institute La Fe, Valencia, Spain

5. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain

6. Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario Dr. Peset, Valencia, Spain

7. Institute of Chemical Technologies and Analytics, Vienna University of Technology, Vienna, Austria

8. Departamento de Química Analítica, Universidad de Valencia, Valencia, Spain

9. Health and Biomedicine, Leitat Technological Center, Valencia, Spain

Abstract

Combining digital images and IR data enhances ATR-FTIR models for liver fat quantification in clinical settings.

Funder

Instituto de Salud Carlos III

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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