A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH-Reference-Cited by-同舟云学术

A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH

Published:2017 Issue:6 Volume:15 Page:1313-1316
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Aikawa H.¹²³⁴⁵,Yano A.¹²³⁴⁵,Nakatani K.¹²³⁴⁵

Affiliation:

1. Department of Regulatory Bioorganic Chemistry

2. The Institute of Scientific and Industrial Research

3. Osaka University

4. Ibaraki 567-0047

5. Japan

Abstract

2,7-Diamino-1,4,8-triazanaphthalene (azaDANP) shows selective binding to a cytosine bulge DNA duplex under weakly acidic conditions, and the absorption change of azaDANP on binding to the target is very sensitive to environmental pH with a bell-shaped absorption–pH profile.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02273A

Reference26 articles.

1. Hydrogen bonds and molecular recognition

2. Hydrogen bonds in protein–DNA complexes: Where geometry meets plasticity

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4. Regulation of Gene Expression by Synthetic DNA-Binding Ligands

5. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

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