Improved anti-breast cancer activity by doxorubicin-loaded super stealth liposomes

Author:

Paolino Donatella12,d'Avanzo Nicola12ORCID,Canato Elena3,Ciriolo Luigi4,Grigoletto Antonella3,Cristiano Maria Chiara5,Mancuso Antonia12,Celia Christian678ORCID,Pasut Gianfranco3ORCID,Fresta Massimo4ORCID

Affiliation:

1. Department of Clinical and Experimental Medicine, University of Catanzaro “Magna Græcia”, V.le “S. Venuta”, Catanzaro, I-88100, Italy

2. Research Center “ProHealth Translational Hub”, Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, Campus Universitario “S. Venuta”—Building of BioSciences, Viale S. Venuta, I-88100 Catanzaro, Italy

3. Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Via F. Marzolo 5, I-35131 Padua, Italy

4. Department of Health Science, University of Catanzaro “Magna Græcia”, V.le “S. Venuta”, Catanzaro, I-88100, Italy

5. Department of Medical and Surgical Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario “S. Venuta”—Building of BioSciences, Viale S. Venuta, I-Catanzaro, Italy

6. Department of Pharmacy, University of Chieti – Pescara “G. d'Annunzio”, Via dei Vestini 31, 66100, Chieti, Italy

7. Lithuanian University of Health Sciences, Laboratory of Drug Targets Histopathology, Institute of Cardiology, A. Mickeviciaus g. 9, LT-44307 Kaunas, Lithuania

8. Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

Abstract

PEGylated dendron phospholipids increase the anchoring effect of PEG to Dox-loaded liposomes, thus improving the pharmacokinetic profile and anti-cancer effect in breast cancer lung metastasis tumor-bearing mice.

Funder

Ministero dell'Università e della Ricerca

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

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