Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp3versus sp2hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity-Reference-Cited by-同舟云学术

Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp3versus sp2hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity

Published:2015 Issue:21 Volume:13 Page:5997-6009
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Slootweg Jack C.¹²³⁴⁵,van Herwerden Eric. F.¹²³⁴⁵,van Doremalen Mark. F. M.¹²³⁴⁵,Breukink Eefjan⁶⁷⁸⁴⁵,Liskamp Rob M. J.¹²³⁴⁵,Rijkers Dirk T. S.¹²³⁴⁵

Affiliation:

1. Medicinal Chemistry and Chemical Biology

2. Utrecht Institute for Pharmaceutical Sciences

3. Department of Pharmaceutical Sciences

4. Faculty of Science

5. Utrecht University

6. Membrane Biochemistry & Biophysics

7. Bijvoet Center for Biomolecular Research

8. Department of Chemistry

Abstract

An alkane-bridged bicyclic nisin mimic with α,β-dehydroamino acids in the backbone was synthesized.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00336A

Reference45 articles.

1. Lantibiotics: biosynthesis, mode of action and applications

2. Biosynthesis and Mode of Action of Lantibiotics

3. Lantibiotics: Insight and foresight for new paradigm

4. Lipid II as a target for antibiotics

5. Lantibiotics: Peptides of Diverse Structure and Function

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