Thermosensitive biomaterial gels with chemical permeation enhancers for enhanced microneedle delivery of naltrexone for managing opioid and alcohol dependency-Reference-Cited by-同舟云学术

Thermosensitive biomaterial gels with chemical permeation enhancers for enhanced microneedle delivery of naltrexone for managing opioid and alcohol dependency

Published:2023 Issue:17 Volume:11 Page:5846-5858
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Tobin Kevin V.¹,Brogden Nicole K.¹²^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences and Experimental Therapeutics, The University of Iowa College of Pharmacy, Iowa City, IA 52242, USA

2. Department of Dermatology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA

Abstract

Naltrexone (NTX) can be transdermally delivered using microneedles (MN) to treat opioid and alcohol misuse disorders, but delivery is blunted by rapid in vivo micropore closure.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D3BM00972F

Reference56 articles.

1. Naltrexone Implant for Opioid Use Disorder

2. Pharmacotherapy of Opioid Use Disorder—Update and Current Challenges

3. Microneedles permit transdermal delivery of a skin-impermeant medication to humans

4. Formation and Closure of Microchannels in Skin Following Microporation

5. Fluvastatin as a Micropore Lifetime Enhancer for Sustained Delivery Across Microneedle-Treated Skin

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