One-pot native chemical ligation of peptide hydrazides enables total synthesis of modified histones
Author:
Affiliation:
1. Tsinghua-Peking Center for Life Sciences
2. Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education)
3. Department of Chemistry
4. MOE Key Laboratory of Protein Sciences
5. Center for Structural Biology
Abstract
One of the rising demands in the field of protein chemical synthesis is the development of facile strategies that yield the protein in workable quantities and homogeneity, with fewer handling steps.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00715H
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1. The language of covalent histone modifications
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