Polymer-controlled core–shell nanoparticles: a novel strategy for sequential drug release
Author:
Affiliation:
1. College of Bioengineering
2. Chongqing University
3. Key Laboratory of Biorheological Science and Technology
4. Ministry of Education
5. Chongqing 400030, PR China
Abstract
Immiscible and miscible liquids were utilized to fabricate PVP/PLGA and PCL/PLGA nanoparticles with a distinct core–shell structure by coaxial electrospray. Two different sequential drug release profiles from different nanoparticles were observed. The melanoma cells and endothelial cells can be sequentially targeted and killed by therapeutic agents released from nanoparticles.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA03610G
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