Solubility enhancements through crystalline solid solutions, the non-linear Tammann diagram and the <i>T</i>–<i>X</i> phase diagram of salicylic acid

Solubility enhancements through crystalline solid solutions, the non-linear Tammann diagram and the T–X phase diagram of salicylic acid–benzoic acid

Published:2023 Issue:17 Volume:25 Page:2607-2617
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Mohajerani Seyed Sepehr¹,Ricci Francesco²,Nordstrom Fredrik L.²^ORCID

Affiliation:

1. Department of Physics, Stevens Institute of Technology, Hoboken, NJ, Unites States

2. Material & Analytical Sciences, Boehringer-Ingelheim, Ridgefield 06877, Connecticut, USA

Abstract

The T–X phase diagram of salicylic acid–benzoic acid discloses significant miscibility in the solid-state. The two crystalline solid solutions result in 87% and 19% solvent solubility increases, respectively, relative to the pure components.

Funder

Boehringer Ingelheim

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CE/D3CE00152K

Reference23 articles.

1. Organic Solid Solution Composed of Two Structurally Similar Porphyrins for Organic Solar Cells

2. Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations

3. Formation of Macrotubular Crystals of Salicylic Acid through Ripening of Solid Solution Crystals Containing Impurity Gradients

4. Enantiotropic inconstancy, crystalline solid solutions and co-crystal in the salicylic acid–anthranilic acid system

5. The solid–liquid phase diagrams of binary mixtures of even saturated fatty alcohols

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