Hydroxy-directed fluorination of remote unactivated C(sp<sup>3</sup>)–H bonds: a new age of diastereoselective radical fluorination-Reference-Cited by-同舟云学术

Hydroxy-directed fluorination of remote unactivated C(sp³)–H bonds: a new age of diastereoselective radical fluorination

Published:2022 Issue:23 Volume:13 Page:7007-7013
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Harry Stefan Andrew¹^ORCID,Xiang Michael Richard¹,Holt Eric¹,Zhu Andrea¹,Ghorbani Fereshte¹,Patel Dhaval¹,Lectka Thomas¹

Affiliation:

1. Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD, 21218, USA

Abstract

We report a photochemical, hydroxy-directed fluorination that addresses the prevailing challenge of high diastereoselectivity. Numerous motifs showcase a range of regio- and stereochemical outcomes based on the configuration of the hydroxy group.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01907H

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