Solid-phase synthesis of branched oligonucleotides containing a biologically relevant dCyd341 interstrand crosslink DNA lesion

Author:

Taverna Porro Marisa L.12345ORCID,Saint-Pierre Christine12345ORCID,Gasparutto Didier12345ORCID,Ravanat Jean-Luc12345ORCID

Affiliation:

1. Univ. Grenoble Alpes

2. CEA

3. CNRS IRIG/SyMMES

4. F-38054 Grenoble Cedex 9

5. France

Abstract

Branched oligonucleotides containing a biologically relevant DNA lesion, involving an interstrand crosslink between a cytosine base on one strand and a ribose moiety on the opposite strand, were prepared in a single automated solid-phase synthesis.

Funder

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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