Stability-indicating chromatographic determination of hydroquinone in combination with tretinoin and fluocinolone acetonide in pharmaceutical formulations with a photodegradation kinetic study

Author:

Abbas Samah S.12345,Elghobashy Mohamed R.12345,Bebawy Lories I.675,Shokry Rafeek F.675

Affiliation:

1. Analytical Chemistry Department

2. Faculty of Pharmacy

3. Cairo University

4. 11562 Cairo

5. Egypt

6. National Organization for Drug Control and Research (NODCAR)

7. Cairo

Abstract

Stability indicating HPLC and TLC-densitometric methods for the determination of hydroquinone, tretinoin, fluocinolone acetonide, their degradation products and preservatives.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference33 articles.

1. J. O. Neil , The Merck Index An Encyclopedia of Chemicals, Drugs and Biologicals, Whitehouse Station, N.J., USA, 14th edn, 2006

2. Development and validation of a fast chromatographic method for screening and quantification of legal and illegal skin whitening agents

3. I.-H. Chiu , Analytical Method Development of Pigment Lightening Ointments by High Performance Liquid Chromatography and Their Stability Study, Chaoyang University of Technology, 2007

4. A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations

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