Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin-Reference-Cited by-同舟云学术

Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin

Published:2020 Issue:5 Volume:56 Page:822-825
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Low Zhen Jie¹²³,Xiong Juan¹²³⁴⁵,Xie Ying¹²³,Ma Guang-Lei¹²³,Saw Howard¹²³,Thi Tran Hoa¹²³,Wong Soo Lin¹²³,Pang Li Mei¹²³,Fong July⁶²³,Lu Peng¹²³,Hu Jin-Feng⁴⁵⁷⁸,Liang Yang⁹¹⁰¹¹¹²⁸,Miao Yansong¹²³,Liang Zhao-Xun¹²³⁶²^ORCID

Affiliation:

1. School of Biological Sciences

2. Nanyang Technological University

3. Singapore

4. School of Pharmacy

5. Fudan University

6. The Singapore Centre for Environmental Life Sciences Engineering (SCELSE)

7. Shanghai

8. China

9. School of Medicine

10. Southern University of Science and Technology

11. Shenzhen

12. Guangdong

Abstract

Genome-guided discovery of a novel linear polyene-polyol that induces ergosterol aggregation and inhibits hyphal growth.

Funder

National Research Foundation Singapore

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/C9CC08908J

Reference50 articles.

1. The antifungal pipeline: a reality check

2. Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations

3. Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group

4. Liposomal Amphotericin B

5. Amphotericin B: Time for a New "Gold Standard"

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