SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases-Reference-Cited by-同舟云学术

SNAr reaction in aqueous medium in the presence of mixed organic and inorganic bases

Published:2015 Issue:39 Volume:5 Page:31226-31230
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Shelke Nilesh B.¹²³⁴,Ghorpade Ramrao¹²³⁴,Pratap Ajay¹²³⁴,Tak Vijay⁵²³⁴,Acharya B. N.¹²³⁴

Affiliation:

1. Process Technology Development Division

2. Defence R & D Establishment

3. Gwalior-474002

4. India

5. Vertox Laboratory

Abstract

N-Arylation of amines with fluorobenzonitriles in aqueous medium is described. A mixture of N,N-diisopropylethyl amine and Na₂CO₃ (1 : 1) is found to achieve maximum conversion by refluxing for 3 hours in water.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA03510D

Reference42 articles.

1. Imidazol-1-yl and pyridin-3-yl derivatives of 4-phenyl-1,4-dihydropyridines combining Ca2+ antagonism and thromboxane A2 synthase inhibition

2. Unexpected Dealkylation During Nucleophilic Substitution: Synthesis of 2-N,N-Dialkylamino Benzoxazoles and Benzothiazoles

3. Catalyst-Free N-Arylation Using Unactivated Fluorobenzenes

4. Aromatic Nucleophilic Substitution (SNAr) of meso-Nitroporphyrin with Azide and Amines as an Alternative Metal Catalyst Free Synthetic Approach To Obtain meso-N-Substituted Porphyrins

5. Sequential Direct SNAr Reactions of Pentafluorobenzenes with Azole or Indole Derivatives

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